We hear so many different versions of CBD, mostly due to the confusion created from the Marijuana plant it originates from, and with CBD becoming more popular in conversation we here at CBD Guy though we would try and explain CBD to our readers.
Firstly CBD is an acronym for Cannabidiol (CBD) and is actually derived from the Hemp plant, a cousin of the Marijuana plant, and Hemp is fundamentally different than the famous Marijuana cousin, we believe a large part of the confusion also stems from the fact that CBD is also one of the components of the Marijuana plant, whilst most of the CBD you will find on the web actually comes from Hemp, in the Cannabis plant it is the second most abundent cannabinoid after its famous partner tetrahydrocannabinol (THC), this THC being the part that makes you “high”
CBD itself has many potential therapeutic benefits, including anti-inflammatory, analgesic, anti-anxiety, and seizure-suppressant properties. CBD can be sourced from both marijuana and hemp plants.
Can you get high on CBD?
While CBD is a component of marijuana (one of hundreds), by itself it does not cause a “high.” According to a report from the World Health Organization, “In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD.”
The Evidence for cannabidiol health benefits
CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and, in some cases, it was able to stop them altogether. Videos of the effects of CBD on these children and their seizures are readily available on the Internet for viewing, and they are quite striking. Recently the FDA approved the first ever cannabis-derived medicine for these conditions, Epidiolex, which contains CBD
How CBD works
CBD’s actions within the brain and body are quite complicated. It’s very likely that the beneficial effects of CBD operate through diverse biological pathways, rather than by a single action. More research is needed to fully understand the mechanisms by which CBD relieves ailments such as seizures.
CBD directly interacts with several proteins in the body and central nervous system, a few of which are components of the endocannabinoid system (ECS). CBD has an affinity for both the CB1 and CB2 cannabinoid receptors. Our bodies have several other receptor proteins that participate in the endocannabinoid system, such as GPR3, GPR6, TRPV1, and TRPV2, for example. CBD binds to all of these, and its possible anti-inflammatory and pain-relieving effects may occur through these pathways.
CBD has some other very important roles outside the ECS. For instance, CBD mildly activates one of the brain’s predominant serotonin receptors (5-HT1A) in mice, which may explain its supposed effects on depression and anxiety. It also acts at the peroxisome proliferator-activated receptors (PPARs) in mice, which may indicate its usefulness in fighting inflammation.
CBD can affect liver function, however. Similar to grapefruit, CBD can inhibit certain drug-metabolizing enzymes in the liver, resulting in much higher levels of some prescription medications in the bloodstream. If you are taking medication, check with your physician before using CBD.
Is CBD a drug?
CBD fits the definition of a psychoactive substance as it can subtly alter perception and mood. However, it’s important to reiterate that unlike weed, CBD does not cause intoxication. CBD is a non-intoxicating substance, so it cannot stimulate the level of sensory and psychological effects that THC does.