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CBD Guy CBD and Diabetes

CBD and Diabetes

Diabetes is a condition in which your body does not process sugar properly, it can cause nerve damage, eye problems, heart disease and stroke. Symptoms include fatigue, blurred vision, feelings of thirst, slow healing of cuts and bruises, diabetic neuropathy, (the condition most often affects the legs and feet. For some people, symptoms are mild. For others, symptoms can be painful, debilitating and even fatal. Symptoms include pain and numbness in the legs. In more severe cases, symptoms include issues with digestion, the bladder and controlling heart rate.Treatment includes managing blood sugar and using medication to control symptoms)

Having a diet high in sugar and refined carbohydrates sends our CB1 receptors into overdrive and disrupts our Endecannabinoid System (ECS) tone, leading to poor appetite and weight gain, leading to the possibility of metabolic disease, and possibly diabetes.

We also know that the ECS plays an integral role in regulating glucose metabolism and insulin sensitivity and how well our body process blood sugar, and that insulin resistance and high blood sugar leads to diabetes, so enhancing ECS tone through the use of CBD makes sense overall.

Preliminary research done has been promising, and in 2006 a research study by Israeli team found that CBD treatment significantly reduces the incidence of diabetes in NOD mice from an incidence of 86% in non-treated control mice to an incidence of 30% in CBD-treated mice.

CBD treatment also resulted in the significant reduction of plasma levels of the pro-inflammatory cytokines, IFN-gamma and TNF-alpha. Th1-associated cytokine production of in vitro activated T-cells and peritoneal macrophages was also significantly reduced in CBD-treated mice, whereas production of the Th2-associated cytokines, IL-4 and IL-10, was increased when compared to untreated control mice.

Histological examination of the pancreatic islets of CBD-treated mice revealed significantly reduced insulitis. Our results indicate that CBD can inhibit and delay destructive insulitis and inflammatory Th1-associated cytokine production in NOD mice resulting in a decreased incidence of diabetes possibly through an immunomodulatory mechanism shifting the immune response from Th1 to Th2 dominance.

The endogenous cannabinoid system participates in the regulation of energy homeostasis, regulation also of glucose homeostasis. It appears to play a very important regulatory role in the secretion of hormones. The important elements of this system are endocannabinoid receptors (types CB1 and CB2). The endocannabinoid receptors are distributed both in the central and peripheral nervous system, in multiple peripheral tissues. They are also localized on islets of Langerhans. Endocannabinoid system plays role in regulation of endocrine secretion in the human pancreas. The endocannabinoid system regulates not only the central and peripheral mechanisms of food intake, but also lipids synthesis and turnover in the liver and adipose tissue as well as glucose metabolism in muscle cells.

How do you take CBD oil?

CBD oil is produced by extracting CBD from the cannabis plant and diluting it with a carrier oil, such as coconut or hemp seed oil.

Forms of CBD

Forms of CBD that you can use to potentially relieve symptoms of diabetes include:

  • Vaping. Inhaling vaporized CBD oil (with the use of vaping pens or e-cigarettes) is the fastest way to experience effects. Compounds are absorbed directly from the lungs into the bloodstream. However, vaping could cause other harmful side effects such as airway irritation or damage.
  • Oils and tinctures. Oils placed (via dropper) under the tongue absorb quickly into the bloodstream. Drops can also be added to foods or beverages.
  • Edibles. These gummy-like candies or chocolates are good options for those who have trouble swallowing pills. Time from ingestion to effect can take a while.
  • Pills and capsules. CBD pills and capsules contain a version of an oil or tincture. The time from ingestion to effect can take a while.
  • Skin creams and lotions. Topical CBD creams are often applied to the skin to ease muscle or joint pain. Most topicals don’t enter the bloodstream. Instead, they affect local cannabinoid receptors in the skin.


Talk with a doctor about which CBD brands and products may be best for you and at what dosage you should start your treatment.

When starting any new drug or supplement, it’s usually best to start with a low dose. This way you can see how well you tolerate it and whether it’s effective at that dose.

Side effects of CBD

An extensive review of CBD’s existing clinical data and animal studies reported that CBD is safe and has few, if any, side effects for adults.

Most common side effects are:

  • fatigue
  • nausea
  • changes in appetite
  • changes in weight


Since CBD is often used in addition to other prescriptions or over-the-counter drugs, more research is needed to understand how the cannabinoid interacts with other meds.

Using CBD may increase or inhibit another drug’s effectiveness or side effects. Talk to your doctor before taking CBD.

This is especially important if you’re taking medications that come with a “grapefruit warning.” Grapefruit and CBD both interact with an enzyme that’s vital to drug metabolism.

Talk to a doctor

Until such time that it’s proven to be an effective treatment, use CBD with caution and with low expectations if you decide to try it.

If you’re concerned about whether it’s safe for you, talk with a healthcare provider. They can help you determine the proper dosage and form to try.

If you do try CBD or CBD oil, remember that it should be used as a complement to your normal diabetes treatment and not a replacement for proven therapy.

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